ICRA 2011 Paper Abstract

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Paper WeP207.1

Han, Mingli (Nanyang Technological University), Zhang, Yan Liang (University of Toronto), Yu, Meng Ying (Nanyang Technological University), Shee, Cheng Yap (Nanyang Technological University, Singapore), Ang, Wei Tech (Nanyang Technological University)

Real-Time Modeling and Control of the Circular Cell Membranes Strain

Scheduled for presentation during the Regular Sessions "Micro-Nano Robots and Applications to Life Science" (WeP207), Wednesday, May 11, 2011, 15:25−15:40, Room 5B

2011 IEEE International Conference on Robotics and Automation, May 9-13, 2011, Shanghai International Conference Center, Shanghai, China

This information is tentative and subject to change. Compiled on December 8, 2019

Keywords Medical Robots and Systems, Micro/Nano Robots

Abstract

Making changes of cells function by regulating the external mechanical environment is one of the major interests in the mechanobiology field. Based on extensive studies, force at nano-to-micro newton and geometric shape changes at nano-to-micrometer are the physical stimuli that can be sensed by cells. It has been postulated that controllable cell responses can be produced by activating diversity of mechanosesory proteins through physical changes of force or shape. In this paper, a real-time machine vision algorithm is proposed to improve the efficiency and robustness of the cell membranes strain calculation. The proposed adaptive image thresholding method with modified numerical implementation is able to apply on all the images captured in the deforming process to extract the deformed cell boundary in real-time. Based on the proposed method, the cell membrane strain is modeled and controlled to deform the cell into a predefined deformation. It enables biologists to study the biochemical changes within the cell by providing a controllable geometric changes. It also expects that a particular cell status or function could be produced by giving a proper deformation.

 

 

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